Introduction: Human saliva contains a wealth of proteins that can be monitored for disease diagnosis and progression.Saliva, which is easy to collect, has been extensively studied for the diagnosis of numerous systemic and infectious diseases.However, the presence of amylase, the most abundant protein in saliva, can obscure the detection of low-abu
EUTHYROID GOITER AS RISK FACTOR OF PERINATAL COMPLICATIONS
The spread of thyroid diseases among women of fertile age are constantly increasing.The frequency of euthyroid goiter occupies one of the first places among the pregnant and constitutes from 30% to 40% according to the data of various authors.At the same time, it has an unfavorable influence on the health of a future mother and it is dangerous for
Distinct resting-state effective connectivity of large-scale networks in first-episode and recurrent major depression disorder: evidence from the REST-meta-MDD consortium
IntroductionPrevious studies have shown disrupted effective connectivity in the large-scale brain networks of individuals with major depressive disorder (MDD).However, it is unclear whether these changes differ between first-episode drug-naive MDD (FEDN-MDD) and recurrent MDD Soap Pump (R-MDD).MethodsThis study utilized resting-state fMRI data from
From Qualitative to Quantitative AOP: A Case Study of Neurodegeneration
Adverse outcome pathways (AOPs) include a sequence of events that connect a molecular-level initiating event with an adverse outcome at the cellular level for human health endpoints, or at the population level for ecological endpoints.When there is enough quantitative understanding of the relationships between key events in an AOP, a mathematical m